Share
Apoptosis in Aspergillus fumigatus
Natália Silva Da Trindade
(Author)
·
Enyara Rezende Morais
(Author)
·
Célio Dias Santos Júnior
(Author)
·
LAP Lambert Academic Publishing
· Paperback
Apoptosis in Aspergillus fumigatus - Silva Da Trindade, Natália ; Rezende Morais, Enyara ; Dias Santos Júnior, Célio
Choose the list to add your product or create one New List
✓ Product added successfully to the Wishlist.
Go to My Wishlists
Origin: U.S.A.
(Import costs included in the price)
It will be shipped from our warehouse between
Friday, July 19 and
Friday, July 26.
You will receive it anywhere in United Kingdom between 1 and 3 business days after shipment.
Synopsis "Apoptosis in Aspergillus fumigatus"
Aspergillus fumigatus is a highly pathogenic fungus for immunocompromised patients and invasive aspergillosis exhibits mortality rates around 50-80%. Thus, the apoptosis pathway in this fungus may be an important target for the development of new drugs. From a data bank, we analyzed five different proteins (Bax, Bir, Nma111, Pca1, and Rad9) belonging to the apoptosis pathway in the genome of Aspergillus fumigatus. Phylogenetic trees, splits graphs, recombination analyses, and assessment of selection strength from codon to codon were developed to understand the evolution and the function of these proteins in the fungus. Our results suggest a conservation of these proteins in the Aspergillaceae family, as well as a low rate of gene recombination with a putative preservation of the function. We thus propose that the apoptosis pathway in Aspergillus fumigatus is started with the Rad9 protein followed by the activation of Bax and Pca1 proteins. Also, Nma111 cleaves the Bir protein resulting in the consequent activation of the Bax protein. Further studies are necessary to better understand the apoptosis process in Aspergillus fum
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
All books in our catalog are Original.
The book is written in English.
The binding of this edition is Paperback.
✓ Producto agregado correctamente al carro, Ir a Pagar.
