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portada Neurodegenerative Diseases
Type
Physical Book
Publisher
Year
1996
Language
English
Pages
482
Format
Hardcover
ISBN
0306452987
ISBN13
9780306452987
Edition No.
1996

Neurodegenerative Diseases

Gary Fiskum; International Washington Spring Symposiu (Author) · Springer · Hardcover

Neurodegenerative Diseases - Gary Fiskum; International Washington Spring Symposiu

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£ 229.18

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Origin: U.S.A. (Import costs included in the price)
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Synopsis "Neurodegenerative Diseases"

This book presents much of the exciting new information on mechanisms of neurodegenerative disorders that was presented at the XVth International Spring Symposium on Health Sciences at George Washington University in Washington, D.C. The organization of the symposium as weIl as the chapters within this book were based upon fundamental molecular and cellular mechanisms of neurodegeneration rather than upon different clinically defined disorders, in order to emphasize the commonality of cause rather than effect. The first part of the book is devoted to the relationships between selective vulnerability of different neuronal cell types to injury and their functional characteristics related to the transport, binding, and responses for excitatory amino acids, e.g., glutamate, as weIl as other neurotransmitters involved in toxicity. These relationships are studied in the context of neurodegeneration associated with several disorders including Parkinson's disease, amyotrophic lateral sclerosis (ALS), cerebral ischemia, and AIDS dementia. Part 11 emphasizes the role of amyloid proteins in neurodegeneration but also covers other molecular and genetic risk factors, e.g., expression of different apo lipoprotein isoforms and the involvement of abnormal superoxide dismutase in neuropathology. These topics are applied primarily to the aging brain, Alzheimer's disease, and ALS.

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