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portada Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging (Springer Theses)
Type
Physical Book
Publisher
Year
2018
Language
English
Pages
137
Format
Hardcover
ISBN13
9783319982540
Edition No.
2018
Categories

Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging (Springer Theses)

Anna Siri Luthman (Author) · Springer · Hardcover

Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging (Springer Theses) - Anna Siri Luthman

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Synopsis "Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging (Springer Theses)"

This book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes - a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of a bimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model.

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