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Synthesis and Evaluation of Novel Carbazole Derivatives
Archita Tiwari
(Author)
·
Sujeet Gupta
(Author)
·
Bharat Mishra
(Author)
·
LAP Lambert Academic Publishing
· Paperback
Synthesis and Evaluation of Novel Carbazole Derivatives - Tiwari, Archita ; Gupta, Sujeet ; Mishra, Bharat
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Synopsis "Synthesis and Evaluation of Novel Carbazole Derivatives"
A novel series of substituted carbazole derivatives was synthesized. In the first step, 2-Chloro-9-H-carbazole-3-carbaldehyde formed via vielsmeier-Hack reaction in the presence of DMF and POCl3. The intermediate product formed with the help of the vielsmeier reaction is further treated with a different substituted amine to get a novel carbazole derivative fused with the substituted amine. The structure of substituted carbazole derivative was identified by thin layer chromatography, FT-IR, and 1H NMR. With the help of the maximal electroshock model (MES), the potency of synthesized compounds was determined based on their reduction of convulsions at different time intervals. Among all the synthesized compounds, compound 4e showed the maximal anticonvulsant activity. Compound 4c and compound 4f also showed better anticonvulsant activity.
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The book is written in English.
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