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Approach to the genetic study of epithelial ovarian cancer
Ángeles García Aliaga
(Author)
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Our Knowledge Publishing
· Paperback
Approach to the genetic study of epithelial ovarian cancer - García Aliaga, Ángeles
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Synopsis "Approach to the genetic study of epithelial ovarian cancer"
Ovarian cancer is the gynecological cancer with the highest mortality, with high-grade serous ovarian cancer accounting for 75% of this pathology, characterized by having an aggressive course and being diagnosed in advanced stages. One of the inclusion criteria according to the Spanish Society of Medical Oncology for high-risk hereditary breast and ovarian cancer syndrome (HOCCOS) is the diagnosis of non-mucinous high-grade epithelial ovarian cancer. SCMOH has an autosomal dominant inheritance pattern in cancer susceptibility genes. Historically, the risk of SCMOH has been mainly linked to germline mutations in BRCA1/2. However, it is now also associated with tumor suppressor genes involved in DNA repair. High-grade ovarian cancer is evidenced by being genetically unstable and approximately 50% of these tumors are deficient in DNA repair mechanisms by homologous recombination.
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The book is written in English.
The binding of this edition is Paperback.
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